Comments on 'an assessment of the role of microdosimetry in radiobilogy" by Dudley T. Goodhead.
نویسندگان
چکیده
Dr. Goodhead proposes to give in his review "a perspective of the evolving role of microdosimetry in the study of radiation effects in mammalian cells," but he also states his intention to "confine this paper to the earlier more narrow usage," i.e., the site concept. A treatment that focuses on a first step that was presented more than a decade ago hardly provides a perspective on a developing theory. In our original paper (1) we primarily treated the site model but pointed out that it was an approximation to the more general distance model. Like any approximation it has limited validity, and it should not be applied when energy deposition in a site is grossly nonuniform. In the meantime and concurrently with designing the molecular (associated) ion experiment, we did develop the generalized version (the distance model). However, in dealing with these and various other issues major mistakes and misconceptions are propagated which are enumerated below. Items (1) and (2) reflect lack of familiarity with experimental microdosimetry; (3) is a misconception relating to an elementary application of microdosimetry to radiobiology; (4) is a misrepresentation of the essence of our theory; (5) is an incorrect definition of a function basic to Dr. Goodhead's argument; (6) is an erroneous specification of the nature of this function; (7) and (8) equate the theory of dual radiation action with the site model approximation, and specifically, (8) purports to show disagreement of experimental results with the theory when it is misapplied in the form of an unsuitable approximation; (9) implies that the theory of dual radiation action supports the "linear hypothesis" of dose-effect relations in radiological protection. Apart from being based on faulty reasoning this is diametrically opposed to our position.
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ورودعنوان ژورنال:
- Radiation research
دوره 93 3 شماره
صفحات -
تاریخ انتشار 1983